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BioWorld - Sunday, April 26, 2026
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Abstract molecules illustration
OI 2022

NOV-004: a promising agent for osteogenesis imperfecta

Sep. 9, 2022

Quince Therapeutics Inc. (formerly Novosteo Inc.) has presented data on NOV-004, a construct that delivers abaloparatide therapeutic agent into the fracture site, designed for the treatment of osteogenesis imperfecta.


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EFMC-ISMC 2022

BI-456906 shows strong body weight lowering efficacy in DIO mice

Sep. 9, 2022
Researchers from Boehringer Ingelheim Pharma GmbH & Co. KG presented preclinical data for BI-456906, a novel long-acting glucagon (GCG)/glucagon-like peptide-1 (GLP-1) dual receptor agonist, currently in phase II development in patients with obesity and nonalcoholic steatohepatitis (NASH).
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Infection

Otcpharm patents compounds for treating influenza A infections

Sep. 9, 2022
Otcpharm JSC has described 2-acetamido-6-hydroxy-benzothiophene compounds reported to be useful for the treatment of influenza A infections.
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Close-up of eye with digital focus
EFMC-ISMC 2022

RG-7774, a novel CB2 receptor agonist with potency and efficacy across species

Sep. 9, 2022
Researchers from Roche Holding AG disclosed the discovery and preclinical evaluation data for RG-7774 (vicasinabin), a novel cannabinoid CB2 receptor (CB2R) agonist being developed for the treatment of diabetic retinopathy (DR).
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Ophthalmic

Fundraising at Kuria Therapeutics to advance topical ophthalmic Nrf2 activator

Sep. 9, 2022
Kuria Therapeutics Inc. has closed its first fundraising round to support ongoing preclinical development activities ahead of a planned series A raise.
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Diagnostics

New nerve-specific fluorophores could advance fluorescence-guided surgery

Sep. 9, 2022
Fluorescence-guided surgery using tissue-specific fluorophores as contrast agents could significantly enhance surgical outcomes.
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Cardiovascular illustration
Cardiovascular

Regnase-1-overexpressing AAV2-ESGHGYF ameliorates pulmonary hypertension in mice

Sep. 9, 2022
Pulmonary hypertension (PH) is characterized by persistent increases of pulmonary arterial pressure that can lead in the long term to right ventricular failure.
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EFMC-ISMC 2022

NR2F6 antagonist TES-4207 shows promising preclinical results for cancer

Sep. 9, 2022
The interaction of immune checkpoints, such as programmed cell death protein 1 (PD-1) or cytotoxic T-lymphocyte antigen-4 (CTLA-4), with their ligands leads to T-cell deactivation, allowing cancer cells to escape from the immune system.
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Cancer cells being destroyed by immunotherapy
Immuno-oncology

H-Cyte adds Jantibody to pipeline

Sep. 9, 2022
H-Cyte Inc. has completed its acquisition of Jantibody, a novel cancer immunotherapeutic agent that has demonstrated promising efficacy in controlling ovarian cancer and mesothelioma in preclinical models.
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Cancer

New galectin-1/galectin-3 inhibitors identified at Idorsia

Sep. 9, 2022
Idorsia Ltd. has discovered hydroxyheterocycloalkane-carbamoyl derivatives acting as galectin-1 (LGALS1) and/or galectin-3 (LGALS3) inhibitors.
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