The U.K. is setting up a nationwide registry of people with dementia, who will be pre-screened and consented, to speed up recruitment to clinical trials and collect real-world evidence of effectiveness once therapies are approved.

Researchers from Connecta Therapeutics SL and the Centre for Genomic Regulation (Barcelona Institute of Science and Technology) recently presented preclinical results on CTH-120, a potential first-in-class allosteric modulator of tropomyosin receptor kinase B (TrkB) designed to enhance neuroplasticity and restore neuronal function in fragile X syndrome.

Researchers from United Arab Emirates University presented the preclinical characterization of ST-2657, a dual G9a/H3R modulator, in a preclinical model of autism.

The Alzheimer’s Association International Conference (AAIC) is the world’s biggest dementia conference. And at the AAIC 2026 meeting, there is big buzz around tau. Sunday’s plenary speaker Ryan Watts, CEO of Denali Therapeutics Inc., highlighted tau-lowering agents as being among the most exciting themes of the conference. “At this conference, we’re going to see additional clinical data that may validate [tau as] a second target in Alzheimer’s disease, amyloid being the first,” he told the audience.

Mindbeam AI has leveraged generative AI to accelerate the discovery of novel pain therapeutics predicted to have improved liver safety compared to acetaminophen.

News of the unexpected phase III failure of the gene silencing drug Wainua (eplontersen) in the treatment of transthyretin-mediated amyloid cardiomyopathy sent Astrazeneca plc’s shares (NYSE:AZN) down $10.88 to close July 9 at $178.40.