BioWorld - Friday, January 16, 2026

Articles Tagged with ''stroke''

Neurology/Psychiatric

Size matters: microvascular dysfunction in stroke could be targetable therapeutic strategy

April 20, 2023
By Subhasree Nag
A study published online in the Proceedings of the National Academy of Sciences on April 14, 2023, showed that strokes cause numerous changes in gene activity in affected microvessels in the brain, and these changes were potentially targetable with existing or future drugs to alleviate brain injury or improve stroke recovery. Treatments available for stroke are very limited and are mainly focused on the recanalization of the obstructed larger cerebral arteries. However, it is known that strokes affect the cerebral microvasculature too, for which there are no current therapies in the clinic.
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Hemorrhagic stroke concept art

FDA clears Rapidai tool to detect, triage patients at high risk of stroke

April 19, 2023
By Meg Bryant
Rapidai Inc. received FDA 510(k) clearance for its Rapid NCCT Stroke technology, the latest tool in its portfolio of non-contrast-based solutions for shock and trauma care. The company claims it is the first and only medical device cleared by the agency to detect suspected intracranial hemorrhage (ICH) and large vessel occlusion (LVO) from value-based CT imaging.
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Brainomix - 360 E aspects software

Brainomix receives FDA clearance for stroke AI imaging software

March 21, 2023
By Shani Alexander
Brainomix Ltd. received U.S. FDA clearance for its Brainomix 360 E-aspects tool, a fully automated AI-imaging solution for stroke assessment. Powered by explainable AI, the Brainomix 360 E-aspects tool, which is already CE-marked, assesses non-contrast CT scans to automatically generate a score and measures the volume of ischemic signs. It also features an overlaid heatmap to visually assist clinicians when treating stroke patients.
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Woman and 3D brain

High bilirubin levels worsen stroke outcomes by aggravating brain damage

March 15, 2023
By Helen Albert
High levels of bilirubin exacerbated damage to neurons in the brain caused by a stroke by binding to the TRPM2 channel, which helped regulate cell death among other processes. The research, published March 14, 2023, in Neuron, showed that blocking the binding site for bilirubin in a mouse model led to improvements in neurotoxicity suggesting some potential for the development of new stroke therapeutics.
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Cross-section of brain
Neurology/Psychiatric

High bilirubin levels worsen stroke outcomes by aggravating brain damage

March 15, 2023
By Helen Albert
High levels of bilirubin exacerbated damage to neurons in the brain caused by a stroke by binding to the TRPM2 channel, which helped regulate cell death among other processes. The research, led by Shanghai Jiao Tong University School of Medicine and the University of Toronto and published March 14, 2023, in Neuron, showed that blocking the binding site for bilirubin in a mouse model led to improvements in neurotoxicity suggesting some potential for the development of new stroke therapeutics.
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Hemorrhagic stroke concept art
Cardiovascular

New mouse model of IVH shows local inflammation and no cognitive impairment

Feb. 15, 2023
Scientists from the National Institutes of Health and affiliated organizations established a novel mouse model of intraventricular extension of hemorrhage (IVH) for the purpose of measuring motor and cognitive function in acute and chronic stages of intracerebral hemorrhage, which is the most severe stroke subtype.
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