LONDON – New human brain organoids that precisely model the three hallmarks of Alzheimer’s disease – amyloid plaque-like lesions, progressive neuronal death and abnormal accumulations of tau – are now ready to be developed for use in high-throughput drug screening.
BioWorld looks at translational medicine, including: X chromosome is finished;
Protein degradation system targeted to KRAS; Bacteriophages find, fight microbiome’s dark side; Preventing T-cell rejection; Mitochondria, interneurons, cognition link explored.
Keeping you up to date on recent developments in diagnostics, including: Predicting likelihood of rare disease; X chromosome is finished; Cotesting improves detection of cervical cancer; Single-cell studies give insights into pulmonary fibrosis.
Keeping you up to date on recent developments in orthopedics, including: Primitive stem cells point to new bone grafts for stubborn-to-heal fractures; Orthopedic surgeons issue guidelines on resuming elective surgery amid COVID-19 pandemic; Cardiac CT can double as osteoporosis test; Novel bone imaging approach provides insights into the progression of knee osteoarthritis.
Keeping you up to date on recent developments in oncology, including: Single-cell RNA sequencing sheds new light on ependymoma in pediatric patients; Immunicom, Sheba Medical team up on immunopheresis for cancer; New study confirms link between infarct, cancer mortality.
Keeping you up to date on recent developments in cardiology, including: Noncoding mutations contribute to heart disease; Link between heart, kidney inflammation following heart attack; Study: Women on beta blockers face higher risk of heart failure with acute coronary syndrome.
The checkpoint molecule CD47 has high hopes riding on it in oncology as being the innate immune equivalent of PD-1. Multiple companies are developing blockers against CD47 and/or its ligand, SIRPa, for the treatment of various tumors.
Keeping you up to date on recent developments in neurology, including: Hospital improves on-time administration of medication to Parkinson patients; Scientists develop Alzheimer's drug-testing platform, discover protective gene; Blood-based biomarker can detect, predict severity of traumatic brain injury.
BioWorld looks at translational medicine, including: Base editor targets mitochondrial DNA; Everyone’s an immune cell; Brief anemia helps out nanoparticle drugs; Crosstalk between sex, stress hormones affects immunity; Astrocytes, endocannabinoids, metabolism cooperate to affect behavior; CDK-like kinase plays role in sensing pain; RNA editing restores Rett protein; Single-cell studies give insights into pulmonary fibrosis.
Keeping you up to date on recent developments in diagnostics, including: Diagnosing fatty liver disease; Assessing COVID-19 with lung ultrasound; Noncoding mutations contribute to heart disease.
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