BioWorld looks at translational medicine, including: Mechanisms of retinopathy come into focus; New partner in crime for AHR; Multiple sclerosis’ early days; MMA induces EMT; CAR T cells for inhibition; Islet organoids can evade immune attack, Cross-reactive immunity helps antitumor response; How antidepressants inhibit fibrosis; Just add fever.
Stimulator of interferon genes (STING) is a protein that senses DNA in the cytosol, where it comes from either an infectious invader or a damaged nucleus and sets off an immune response that ultimately results in the activation of T cells. STING agonists are among the strategies that have been tested in hopes they would increase the response rate to checkpoint blockade. Now, back-to-back papers in the Aug. 21, 2020, issue of Science have detailed the preclinical development of orally available STING agonists.
A Sino-U.S. collaborative study has demonstrated that acupuncture regulates inflammation by activating pro- or anti-inflammatory signaling pathways, while mitigating cytokine storms in mice with systemic inflammation, the study authors reported in the Aug. 12, 2020, edition of Neuron.
BioWorld looks at translational medicine, including: Oxygen therapy harms lungs via lung, gut microbiome; Turning flexibility into toxicity; Gaining insights into loss of function; Stromal cell subtypes identified in TNBC.
Triggering receptor expressed on myeloid cells 2 (TREM2) was first discovered because variants affect the risk of developing late-onset Alzheimer’s disease (AD).
Investigators have developed a new approach to classifying neurodegenerative disorders that used the overall patterns of protein aggregation, rather than specific proteins, to define six clusters of patients that crossed traditional diagnostic categories.
BioWorld looks at translational medicine, including: PRC member affects blood formation during aging; Localized bile acid improves systemic blood glucose control; After injury, astrocytes can make interneurons; In AML, collapse prevents relapse; Starving out Chlamydia.
Researchers from the Encyclopedia of DNA Elements (ENCODE) consortium reported data from the third phase of the project. Phase III data, which were published in more than a dozen papers in Nature and its sister journals on July 29, 2020, consisted of 6,000 experiments performed on around 1,300 samples.
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